秦天依(博士)，crown中国官方网站副研究员，硕、博导师，海南省拔尖人才，海南省优秀青年基金获得者，三亚崖州湾科技城D类人才。
研究方向：
1) 分子、超分子荧光探针设计。
2) 高毒性、致病性有害物的现场检测、生物成像。
3) 慢性疾病标志物体外即时检测。
招生需求：
欢迎具有分析化学、有机化学、智能分子工程、生物技术工程、物理化学、计算化学等相关专业背景的同学加入
欢迎具备荧光探针、荧光成像、超分子化学等研究经验的博士后加入（/info/1058/7631.htm）
联系方式：qintianyi@hainanu.edu.cn
教育研究经历：
2008-2012：南开大学，化学学院，材料化学，本科（导师：杨化滨）。
2012-2017：中国科学院理化技术研究所，有机化学，博士（导师：李嫕）。
2017-2019：深圳大学，材料学院，博士后（合作导师：刘斌、王雷）。
2020-2022：华南农业大学，植物保护学院，博士后（合作导师：徐汉虹）。
2023-至今：crown中国官方网站，crown中国官方网站，分子靶向成像团队（PI：朱明强教授）
代表论文：
Google scholar: https://scholar.google.com/citations?user=9hYA-KgAAAAJ&hl=zh-CN&oi=ao
(21) Yuting Luo, Linhui Peng, Zhang Lin, Zhiqing Xun, Na Li, Naiyu Liu, Yalong Wang*, Xinfeng Du*, Tianyi Qin*, Bin Liu, Mingqiang Zhu. Engineered albumin host for ratiometric fluorescent indicator-displacement assays: distinguishing testosterone from estrone and estradiol. Chemical Engineering Journal, 2025, Accepted.
(20) Jian Wang, Quan Chen, Zhang Lin, Deteng Zhang, Lu Zhang, Tian-Yi Qin*, Zhao-Hui Wang*, Ya-Long Wang*, Ming-Qiang Zhu. Functionalized nanohydrogel for accelerated skin burn repair with photo-activated bacteria elimination and pro-regenerative protein loading. Chemical Engineering Journal, 2025, 522, 167777.
(19) Ze-Jun Li, Zhen-Yu Zhang, Yao-Yuan Jiang, Yun-Miao Liu, Jian Wang, Ya-Long Wang*, Tian-Yi Qin*, Ming-Qiang Zhu*. Construction of High-Performance Wash-Free Aβ Probes Based on Amino Group Optimization and Amphiphilic Molecular Engineering Strategies. Analytical Chemistry, 2025, 97, 34, 18479–18489.
(18) Caiqiang Liao, Xianwen Liang, Tianyi Qin*, Xinfeng Du, Haoyan Xiong, Quan Chen, Cuizhen Lu, Zhongyang Zhang, Zhongyong Xu, Taoyuze Lv, Zhaohui Wang, Yalong Wang, Bin Liu, Mingqiang Zhu. Regulating the hydrophobic part in amphiphilic triphenylamino-diarylethene fluorophores for ultrasensitive and portable detection of urinary albumin. Sensors and Actuators B: Chemical, 2025, 137592.
(17) Yixin Li, Yujian Cai, Mingyuan Zhang, Zhongyong Xu, Yuting Luo, Yi Cai, Zhiqing Xun, Taoyuze Lv, Yalong Wang*, Tianyi Qin*, Bin Liu, Mingqiang Zhu. Rational design of a ratiometric indicator-displacement assay for the monitoring of chlortetracycline and intracellular imaging. Talanta, 2025, 284, 127251.
(16) Zhenyu Zhang, Zejun Li, Yinghao Tang, Tingting Hou, Liang Xu, Zhaohui Wang, Tianyi Qin*, Yalong Wang*, Mingqiang Zhu. Tailoring near-infrared amyloid-β probes with high-affinity and low background based on CN and amphipathic regulatory strategies and in vivo imaging of AD mice. Talanta, 2025, 281, 126858.
(15) Cuizhen Lu, Liang Xu, Yu Jiang, Caiqiang Liao, Yixin Li, Yinghao Tang, Zhongyong Xu, Xinfeng Du, Taoyuze Lv, Yalong Wang*, Tianyi Qin*, Bin Liu, Mingqiang Zhu. Sensitive and accurate monitoring of urinary albumin and point-of-care testing using a fluorescent probe with anti-interference capacity against exogenous drugs. Talanta, 2024, 435, 137617.
(14) Weihua Deng, Tianyi Qin*, Na Li, Zhongyong Xu, Lei Wang, Mingle Li, Xiaoqiang Chen, Shiwei Zhang, Bin Liu*, Xiaojun Peng, Flavonoid dyes with molecular packing-induced fluorochromism for ratiometric broad-spectrum detection of avermectins. Sensors and Actuators B: Chemical, 2024, 136406.
(13) Cui-Zhen Lu, Cai-Yun Wang, Chao Song, Tianyi Qin*, Taoyuze Lv, Conghui Zeng, Shihong Chen, Zhongyong Xu, Zhiqing Xun*, Bin Liu*, Ya-Long Wang*, Ming-Qiang Zhu. A ratiometric fluorescent indicator-displacement assay for on-site determination and intracellular imaging of nitroxinil. Food Chemistry, 2024, 435, 137617.
(12) Zhen-Yu Zhang, Ze-Jun Li, Ying-Hao Tang, Liang Xu, De-Teng Zhang, Tian-Yi Qin*, Ya-Long Wang*. Recent Research Progress in Fluorescent Probes for Detection of Amyloid-β In Vivo. Biosensors, 2023, 13 (11), 990.
(11) Ze-Jun Li, Cai-Yun Wang, Liang Xu, Zhen-Yu Zhang, Ying-Hao Tang, Tian-Yi Qin*, Ya-Long Wang*. Recent Progress of Activity-Based Fluorescent Probes for Imaging Leucine Aminopeptidase. Biosensors, 2023, 13(7), 752.
(10) Chao Song, Conghui Zeng, Tianyi Qin*, Taoyuze Lv, Zhongyong Xu, Zhiqing Xun, Lei Wang, Xiaoqiang Chen, Bin Liu*, and Xiaojun Peng. A dual-state-emission chalcone-based supramolecular probe for ratiometric detection of penconazole in environmental samples. Chemical Engineering Journal, 2023, 143610.
Selected publications before HNU
(9) Tianyi Qin, Xiongfei Zhao, Chao Song, Taoyuze Lv, Shihong Chen, Zhiqing Xun, Zhongyong Xu, Zhixiang Zhang, Hanhong Xu, Chen Zhao, Bin Liu*, and Xiaojun Peng. A ratiometric supramolecular fluorescent probe for on-site determination of cyfluthrin in real food samples. Chemical Engineering Journal, 2023, 451, 139022.
(8) Tianhao Jia, Chunmei Pu, Tianyi Qin*, Bin Liu, Guangkai Yao, Zhiqing Xun, Bingfeng Wang, Yongqing Tian, Zhixiang Zhang*, Hanhong Xu*, Chen Zhao*. Azocalixarene-Based Supramolecular System for the Detection of Paraquat via an Improved Indicator Displacement Assay. Journal of Agricultural and Food Chemistry, 2022, 70(50), 15981–15989.
(7) Bin Liu*, Mei Zhou, Yingying Huang, Bing Du, Lei Wang, Zhongyong Xu*, Tianyi Qin*, Xiaojun Peng. Rapid and ratiometric fluorescent detection of phosgene by a red-emissive ESIPT-basedbenzoquinolone probe. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2022, 281, 121619.
(6) Tianyi Qin*, Xiongfei Zhao, Tianhao Jia, Shufan Si, Zhongyong Xu, Bin Liu, Hanhong Xu*, and Chen Zhao*. A surfactant-assisted approach enables the fluorescence tracking of benfluralin in plants. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2022, 280, 121517.
(5) Tianyi Qin, Xiongfei Zhao, Tianhao Jia, Xinfeng Du, Taoyuze Lv, Yongqing Tian, Zhixiang Zhang, Bin Liu*, Hanhong Xu*, and Chen Zhao*. A novel protein-based supramolecular recognition approach for ratiometric fluorescence detection of fipronil. Sensors and Actuators B: Chemical, 2022, 369, 132358.
(4) Tianyi Qin, Xiongfei Zhao, Taoyuze Lv, Guangkai Yao, Zhongyong Xu, Lei Wang, Chen Zhao*, Hanhong Xu*, Bin Liu*, and Xiaojun Peng. General method for pesticide recognition using albumin-based host-guest ensembles. ACS sensors, 2022, 7(7), 2020-2027.
(3) Xiongfei Zhao, Weidong Zheng, Tianyi Qin*, Xinfeng Du, Yanmei Lei, Taoyuze Lv, Mei Zhou, Zhongyong Xu, Lei Wang, Bin Liu*, and Xiaojun Peng. An anti-interference fluorescent probe for point-of-care diagnosis of albuminuria. Sensors and Actuators B: Chemical, 2022, 351, 130980.
(2) Tianyi Qin, Bin Liu*, Zhongyong Xu, Guangkai Yao, Hanhong Xu*, and Chen Zhao*. Flavonol-based small-molecule fluorescent probes. Sensors and Actuators B: Chemical, 2021, 129718.
(1) Tianyi Qin, Bin Liu*, Bing Du, Yingying Huang, Guangkai Yao, Zhiqing Xun, Hanhong Xu*, and Chen Zhao*. Solvatofluorochromic flavonoid dyes with enlarged transition dipole moments enable ratiometric detection of methanol in commercial biodiesel with improved sensitivities. Journal of Materials Chemistry C, 2020, 8(47), 16808-16814.
专利：
(1) 王亚龙，张振宇，李泽君，秦天依，朱明强，一种标记Aβ斑块的蓝色水溶性探针及其制备方法和应用，CN202510320433.3。发明公开
(2) 秦天依，廖才强，王亚龙，一种用于尿白蛋快速检测的三苯胺-吡啶鎓盐荧光探针及其制备方法，CN202411911158.4。发明公开
(3) 秦天依，陆翠珍，王亚龙，一种抗药物干扰的尿蛋白荧光探针及其制备方法和应用，CN202410807919.5。发明公开
(4) 赵晨，秦天依，徐汉虹，一种农药荧光标记成像材料及其制备方法和应用，CN202110461547.1。已授权
(5) 刘斌，郑丹娜，秦天依，查尔酮荧光探针及其制备方法与应用、床旁快速检测尿蛋白方法，CN202110705411.0。已授权
(6) 姚光凯，徐汉虹，赵晨，秦天依，一种吡唑并嘧啶化合物及其制备方法和作为荧光探针的应用，CN202210790470.7。已授权
(7) 徐汉虹，秦天依，赵晨，一种基于荧光分析的农药-靶标蛋白筛选方法，CN202110461531.0。已授权
(8) 徐汉虹，秦天依，赵晨，一种基于荧光分析的农药检测方法，CN202110461490.5。已授权
(9) 刘斌，秦天依，一种用于神经毒气模拟物检测的荧光探针、荧光试纸及其制备方法，CN201910309692.0。已授权
科研项目：
1. 海南省自然科学基金-优秀青年基金(224YXQN414)，2024.03~2027.03，主持，在研。
2. 国家自然科学基金委-地区项目(22364012), B04，2024.01~2027.12，主持，在研。
3. 国家自然科学基金委-青年项目(32102243), C14，2022.01~2024.12，主持，结题。
4. 中国博士后基金会-面上项目(2021M691084), 2022.01~2023.12，主持，结题。
研究组成员：
在读：
2023博：张振宇；
2023硕：骆玉婷、彭琳慧、廖才强；
2024硕：易郡鑫、黄丽珍；
2025硕：符小怡、董禹显；
2022本：熊浩言。
已毕业：
2022硕 陆翠珍（宁波康龙化成）；
2022硕 李益欣（）；
2021本 邓权海（海南海一信通科技有限公司）。
个人及指导员工获奖荣誉：
2024 陆翠珍 国家奖学金；
2024 陆翠珍 crown中国官方网站2024-2025年度优秀研究生；
2025 陆翠珍 crown中国官方网站老员工年度人物提名奖；
2025 廖才强 三亚崖州湾科技城第三届研究生学术年会汇报奖（二等）；
2025 骆玉婷 三亚崖州湾科技城第三届研究生学术年会汇报奖（三等）；
2025 张振宇 三亚崖州湾科技城第三届研究生学术年会汇报奖（三等）；
2025 张振宇、李泽君、易郡鑫 第十届全国老员工生物医学工程创新设计竞赛 二等奖。
